The most convenient connection from Frankfurt airport to Darmstadt is the HEAG Airliner which is a bus shuttle service directly to/from the main railway station at Darmstadt. A brochure including a time table can be downloaded here. From there, follow the directions in the next paragraph
You have a couple of choices. Tram (street car) lines are denoted by numbers, bus lines by letters of the alphabet. Take either
You can reach Darmstadt via motorways A5 and A67. Leaving at exit "Darmstadt/Griesheim" and following the signs "Innenstadt" will guide you directly onto "Rheinstraße". Once on "Rheinstraße", please follow the routes on the map to "Schlossgartenstr.".
Campus-Navigation - Gebäude S2/15